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"In fact, there are no head-to-head clinical trials comparing the highest doses of the respective medicines, so Lilly has no basis to make these" claims, Novo Nordisk wrote in the complaint

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For example, increased activity of the endocannabinoid system does not influence GLP-1 concentrations 74,75 , and the effects of CB1 receptor antagonists on appetite, food intake, and weight are not mediated by GLP-1 76,77

Administered through various routes such as injections, oral ingestion, and topical applications, therapeutic peptides have shown remarkable efficacy in reducing inflammation, improving wound healing, and enhancing physical activity

Clinical data show that these symptoms are often temporary and tend to occur during dose escalation

As more clients ask about or begin using GLP-1s, treatment providers are navigating complex new terrain