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however, acute overdose can cause fatal liver damage often heightened with use of alcohol, and the number of accidental self-poisonings and suicides has grown in recent years
Best for: Acute episodes where you need reliable symptom control (travel, important meetings, etc.) Caution: Not for daily long-term use
see, e.g
The authors note that these results contrast with previous research supporting the value of ongoing lifestyle intervention, and suggest that limited sample sizes, intervention heterogeneity, or study designs may have contributed to this unexpected finding
However, as we discussed, they have the lowest bioavailability
Yesand in many cases, the results are noticeable within a few months
