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It may be reasonable to focus on whether the combination of GLP-1RAs and SGLT2is, which are expected to have complementary effects based on large-scale clinical trial results, can further reduce cardiovascular and renal events in patients with diabetes

K., Finnie, M

Abstract Objective The absorption, distribution and elimination of oral semaglutide, the first oral glucagon-like peptide-1 receptor agonist for treating type 2 diabetes, was investigated using a population pharmacokinetic model based on data from clinical pharmacology trials

Open-label extension ACCESS Participants who completed the double-blind treatment period on study drug (or placebo) and signed informed consent ( n = 151) were eligible to enroll in the ACCESS OLE to assess the longer-term safety of aleniglipron, durability and maintenance of weight loss for an additional planned 36 weeks (from weeks 36 to 72)

This way, the efficacy of the solution can be maintained over a period of 28 days