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Lexicomp lists 374 interaction entries for sildenafil as of 2025, including 12 classified as "X: Avoid Combination" (primarily nitrate-containing products) and 48 classified as "D: Consider Therapy Modification" (including alpha-blockers, riociguat, and strong CYP3A4 inhibitors) [1]
When supplementing, you should pay attention to nutrient reference value guidelines, and stay within the safe upper limit
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