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Topical application of PEPITEM not only reduced local inflammation but also had systemic effects, such as reducing disease-related splenomegaly and limiting the expansion of CD4+, CD8+, Th1, and Th17 T-cell populations in the spleen

The remaining trials are still active and will report throughout 2026

[2] [3] Sleep-related complaints, whilst not formally classified as common side effects, may occur indirectly as a consequence of these gastrointestinal disturbances or other metabolic changes associated with treatment

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More recent studies have reported that complex factors, such as infection, environmental exposures, diabetes and metabolic disorders, and genetics, may all contribute to dementia risk

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