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It should be free of any visible particles
The authors of this systematic review searched Ovid MEDLINE, Ovid Embase, the Cochrane Central Register of Controlled Trials and the Cumulative Index to Nursing and Allied Health Literature as well as a host of other databases for anything that reported on the effectiveness or safety of coffee enemas
The BMJ 2014, 348: g2548
Gottenberg JE, Brocq O, Perdriger A et al (2016) Non-TNF-targeted biologic vs a second anti-TNF drug to treat rheumatoid arthritis in patients with insufficient response to a first Anti-TNF drug: a randomized clinical trial