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In my experience, GLP-1s get blamed for a handful of aesthetic side effects that are actually a result of weight loss itselfnot the drug
Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 20 , 2183-2188
Fruits and vegetables have water in them
Some patients experience plateaus earlier, which may respond to dose adjustments or medication switches
A 2025 study published in Obesity found that GLP1 users lost 7.7% of body weight on semaglutide and 12.4% on tirzepatide after one year, roughly half the weight loss seen in randomized trials
So, while they show promising results so far, whether this effect translates to humans, needs more research to answer
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