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Similarities between the pathological features of PCOS and the physiological changes of puberty have been renowned, like menstrual irregularity, increased ovarian and adrenal steroidogenesis, the hyperpulsatile gonadotropin secretion, hyperinsulinemia, diminished levels of sex hormone-binding globulin (SHBG), insulin-like growth factor-binding protein-1 (IGFBP-1), and insulin resistance [29]
BPC-157 works through different mechanisms (NO modulation, growth factor signaling) than these drugs, making pharmacological overlap unlikely
The depot effect in subcutaneous adipose tissue isn't a limitation
Representative blots of at least two independent experiments are shown
Data were processed using statistical software MedCalc (Mariakerke, Belgium)
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