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43 Upon exposure to a series of stress conditions, such as DNA damage, oncogene activation, ribosomal stress, nutrient deprivation, and hypoxia, TD (AA residues 325356) is responsible for the tetramerization of full-length p53 (p53 functions as a tetramer in the process of DNA binding)
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722619 and 734719), and by the Sociedade Portuguesa de Diabetologia
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NNT is therefore essential in the regulation of mitochondrial NADPH production and glutathione redox state (E GSH ), and hence in cell antioxidant defences [18, 19, 21,22,23,24]
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