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As a result of downregulation of Runt-related transcription factor 2 (Runx2) expression, ferroptosis inhibits osteogenic commitment and differentiation in mesenchymal stem cells and pre-osteoblasts, leading to a decrease in alkaline phosphatase and osteocalcin [10]
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Both albiglutide and dulaglutide received FDA approval for the treatment of T2DM in 2014, with dulaglutide having an additional indication since 2020 to reduce the risk of major adverse cardiovascular events (MACE) in adults with T2DM and established cardiovascular disease or multiple cardiovascular risk factors [ Table 2 ]
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These results, published in the New England Journal of Medicine in 2024, exemplify the expanding therapeutic horizons of this drug class
2-Aminoadipic acid is also known as -aminoadipic acid
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