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Increased resting cerebrovascular tone in individuals along the ADRD progression spectrum (Yew and Nation, 2017) is likely to restrict transient increases in blood pressure into the cerebral circulation

Targeting Residual Chemotherapy-Resistant Acute Myeloid Leukemia Cells By a Novel Oxphos Inhibitor IACS010759

Furthermore, crocetin (CRO) has been reported to downregulate total cholesterol (TC) and cholesterol esters (CE), effectively limiting lipid droplet formation and activating PPAR/LXR- to facilitate reverse cholesterol transport, thereby ameliorating atherosclerosis (99)

Importantly, recent research suggests that paternal preconception interventions, such as dietary restriction or exercise, may restore sperm epigenetic integrity and reduce offspring metabolic risk [103]

10.1038/s41392-022-00925-z 158 ZhangQ.XueT.GuanJ.WangW.ShiJ.LuJ.et al (2021d)

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