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It demonstrated protection against H 2 O 2 -induced neurotoxicity in SH-SY5Y cells (a human neuroblastoma cell line) and neuroinflammation in LPS-stimulated BV-2 cells (a microglial cell line)
Similarly, GSH expression is upregulated upon exposure to DEM, rising by up to 30% with increasing DEM concentrations
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doi: 10.1080/0886022x.2023.2292753 18 ZhengYZhangZZhengDYiPWangS
As an example, GSTZ1-1 catalyzes the cis-trans isomerization of 4-maleylacetoacetate to 4-fumarylacetoacetate within the phenylalanine catabolic pathway 21
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