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H-J Bai, D-Y Qi, H-W Li, Y, Molecules 28, (2023) 758
"Improving metabolic health can have positive effects far beyond weight alone," Natesh added
It belongs to a novel class of drugs known as triple agonists, meaning it simultaneously activates three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
The research, published on November 13 in The study, which included around 228,000 people in Sweden, showed a 36% lower risk of hospitalization among those taking semaglutide
In summary, GLP-1RAs have the potential to inhibit neuroinflammation and promote nerve regeneration through the "Tregs-microglia-neuron/NPCs" axis: (1) GLP-1RAs directly and indirectly inhibit the activation of microglia, promote their M2 polarization, and secrete cytokines such as IL-4, IL-10, TGF - , IL-2 to exert anti-inflammatory effects (100)
Kineman et al., 1999)
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