Most excluded studies focused on specific dermatological conditions (acne, psoriasis, radiotherapy-induced dermatitis) rather than addressing general skin health and age-related changes
It works by mimicking two hormones that control appetite, GLP-1 and GIP
Both injectable and nasal spray forms are used in practice, with the choice often depending on patient preference, treatment adherence, and desired intensity of effect

Supplement Facts: Serving Size: 1 Scoop (4.6g) Servings Per Container: 60 Amount Per Serving: Energy: 5 kcal (21 kJ) Total Carbohydrate: 1.0 g Dietary Fiber: 0.2 g Protein: 0 g Fat: 0 g Vitamin C: 173 mg Thiamin (B1): 0.56 mg Riboflavin (B2): 0.78 mg Niacin (B3): 20 mg Vitamin B6: 0.98 mg Vitamin B12: 0.9 mcg Pantothenic Acid (B5): 1.7 mg Chromium Picolinate: 10 mcg *RI - Reference Intake Ingredients: Acetyl L-Carnitine, Inulin Fiber, Conjugated Linoleic Acid (CLA), Grapefruit Seed Extract, Guggul Extract Powder (Guggulsterone), Mangifera Indica, Raspberry Ketones, Oleuropein (Olive Leaf Extract), Green Coffee Bean Extract, Higenamine HCL, Chromium Picolinate, L-Glutamine, Vitamin C (Ascorbic Acid), L-Tyrosine, Taurine, Caffeine Anhydrous, Thiamine Mononitrate (Vitamin B1), Riboflavin (Vitamin B2), Niacinamide (Vitamin B3), Calcium Pantothenate (Vitamin B5), Pyridoxine HCL (Vitamin B6), Cyanocobalamin (Vitamin B12), Natural Flavor, Citric Acid, Sucralose, Silicon Dioxide, Calcium Silicate, Beet & Carrot Juice Powder (Color), Sodium Chloride, Turmeric (Color), DL-Malic Acid, Tartaric Acid, Spirulina Extract (Color), Fruit & Vegetable Juice Powder (Color)

Cutaneous metastases may be any colour but are often black or red
Panel B presents the hypothesis-level mechanistic framework used only to organize subsequent discussion, not to imply confirmed causal mediation