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For all four tested residues, we found that depending on the substitution introduced, the two enzymatic activities were impacted to different extents (Fig
doi: 10.1016/j.thromres.2020.12.002 149
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Among patients treated with resmetirom 80mg or 100mg who achieved a 30% reduction from baseline in MRI-PDFF, NR was observed in 28% and 38% and FR in 17% and 18% more patients than placebo
