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Our studies show that GLP-1 receptor agonists strongly activate the hypothalamic pituitary adrenal (HPA) axis the system that produces stress hormones such as cortisol in humans and corticosterone in preclinical models

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10.1128/spectrum.00170-22 20 BurcelinR.SerinoM.ChaboC.GaridouL.PomiC.CourtneyM.et al (2013)