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Adequate hydration is the first-line response

(L-Carnitine) 1

Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

doi:10.1136/jnnp.2004.057620 27BakkersM, MerkiesIS, LauriaG,

These effects are highest during the titration phase, typically peaking around weeks 6-8 of use, and resolve for the majority of participants as the body adapts, usually by week 10-12