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A chunk of any large weight loss is lean tissue (including muscle), not just fat, which is why I will not stop nagging about protein and the gym
For example, semaglutide often starts at a low dose and increases incrementally over several weeks
Patients should not stop taking Ozempic without medical advice but should seek prompt assessment to determine the underlying cause
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Eating out on GLP-1: restaurant strategies Social life does not stop because you started GLP-1 therapy
Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years
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