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The collagen group showed significant WOMAC pain score improvement: -1.90 4.14 versus +0.61 3.97 for placebo (p=0.006)
Conversely, it increases speroxide dismutase and vessel vasodilation and has been shown to block ultraviolet damage to skin keratinocytes and improve fibroblast recovery after X-ray treatments [6]
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The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving blood flow, and modulation of dopamine and serotonin systems
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