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GSH supplements would seem to be the most efficient way to increase cellular levels of GSH because if significant amounts of GSH are absorbed intact and are biologically active and also if the digestion process breaks down additional amounts of the supplemental GSH into its precursorswhich would then be also absorbed and available for recombination into GSHthe inter- and intracellular GSH transport mechanisms would be shifted in favor of increased cellular GSH
Thus while UA can be influenced by environmental, notably dietary, factors, serum UA is considered to be mainly genetically determined
Mutations conferring GSH-independence map to the protomer interface between proteins VP1 and VP3 and are consistent with GSH binding being essential for the formation of pentameric subunits critical to assembly 24,27
PMID 7999984
Food Preservation 5.4.2.3.10
