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PubMed PMID 39325560, 2024
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Since the PMI hydrogel lacked the on-demand bioactivities to promote cartilage tissue formation, the repair capability of the defects was neglectable
However, clinical trials show that these therapies can improve pain, sensation, and nerve function, which means doctors may use them off-label when there is evidence to support their benefit
If persistent reactions occur, adjusting injection sites or technique usually resolves the problem
In vitro research interest focuses on NNMT inhibition-dependent SAM (S-adenosyl methionine) pool restoration, adipocyte lipid metabolism studies, NAD+ precursor pathway research, and cellular methylation capacity assays
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