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Protein-bound uremic toxins (IS, pCS, PAGln) accumulate exponentially as eGFR declines below 60 mL/min/1.73 m 2 due to saturable OAT1/3-mediated tubular secretion (113, 167), with patients at eGFR 30 exhibiting 510 higher IS than those at eGFR 90reflecting clearance impairment rather than unique pathogenic mechanisms
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In addition, mitoglitazone significantly alleviates renal I/R injury in mice by upregulating GPX4 and reducing iron-related lipid peroxidation
Alwan N & Ghadhban R
In vivo, GMD eliminates senescent cells and downregulates the expression of senescence-associated genes, in a model of whole-body irradiation 34
