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Planta Med 87(04):336346

383,384 Dotinurad, a selective urate reabsorption inhibitor available in Japan, inhibits URAT1 with high selectivity, demonstrating non-inferiority to febuxostat in lowering serum UA levels with no significant safety concerns 385 (Table 4)

[57] For hypertension management, the usual starting dose ranges from 5 to 10 mg once daily, with titration based on blood pressure response

GLP1RA, beyond lowering blood sugar and providing heart and kidney benefits, significantly influence weight management and improve clinical, biochemical, and histological markers of fatty liver and fibrosis in metabolic-associated fatty liver disease (MAFDL) 51

Plus-size retailers could be at risk, with some customers moving out of the category