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Rett syndrome, caused by MECP2 gene mutations, disrupts GABAergic interneuron development, lowering GABA concentrations in the hippocampus and prefrontal cortex, leading to developmental regression, such as loss of language and motor skills, and stereotypic hand movements like hand-wringing (77)
Aug 2014;28(8):2443-2451
At the 10mg/ml concentration, the difference between 25 units and 26 units is 0.1mg, a 4% dosing error on a 2.5mg dose
