The mTOR pathway confers MZB-like properties to GSH-deficient FoB To investigate further the function of GSH in total splenic B cells, we performed a comparative single-cell CITE-seq analysis on B cells from Gclc fl/fl and Gclc fl/fl Mb1-Cre + mice
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208 Insulin-like growth factor binding proteins 1 and 2 (IGFBP1 and IGFBP2, respectively) are the most abundant circulating IGFBPs and have lower concentrations in adipose tissue in obese patients, in addition to being negatively associated with hyperinsulinemia and IR
To address this need, we analyze data from three asthma cohorts, combining up to 25 years of electronic medical records with sequential metabolomics studies, to develop and replicate a predictive model for asthma exacerbation risk
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This discovery led to the development of exenatide, the first GLP-1 receptor agonist approved for type 2 diabetes in 2005