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Sometimes referred to as the sunshine vitamin, vitamin D3 promotes the actions of serotonin, dopamine, and other key brain neurotransmitters

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Surgery, with or without radiation, is considered to be the main local modality in earlier-stage disease, whereas systemic therapy meets the goals of eliminating micro metastatic disease and decreasing the risk of recurrence

We observed higher green fluorescence of JC-1 compared to red aggregated form in GNE knockdown cells, indicative of mitochondrial membrane depolarization (Fig