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GLP-1, or glucagon-like peptide-1, is a hormone your body naturally produces in the gut
Endocrinology 2014 , 155 , 12801290
Answer: Cagrilintide is given as a once-weekly subcutaneous injection, typically self-administered at home after in-office training, with the dose titrated upward over several weeks to reach the target while minimizing nausea
By combining GLP-1 receptor agonism with glucagon receptor activation, it tackles both sides of the weight-loss equation: Less intake through appetite suppression and delayed gastric emptying More burn through increased energy expenditure and hepatic fat metabolism Early Phase 2 data showed double-digit weight loss (up to ~19%), improvements in glycemic control, and reductions in liver fat and fibrosis markers, suggesting its role may extend well beyond weight management into MASH treatment
37 (3), E124
In this setting, they may contribute to maintaining metabolic stability, limiting weight regain, and preserving lean body mass during the post-treatment phase
