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10.1158/2159-8290.Cd-13-0040 Cancer Discov

Despite the contradictory data regarding kidney outcomes, two surrogate outcomes benefit the most from combined therapy: the decline in eGFR slope and the reduction in urinary albumin-to-creatinine ratio

Diabetic ketoacidosis (DKA) risk is a serious concern, particularly for patients using insulin or SGLT2 inhibitors with very-low-carbohydrate diets

Glucagon normally raises blood glucose by signaling the liver to release stored glycogen

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So, uh, there is something to be said about this inflammatory component