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Treatment with Nec-1, a well-established necroptosis inhibitor, can inhibit cell death in vitro , and reduce kidney inflammation and attenuate renal dysfunction in HFD/STZ-induced diabetic mice (74)
488,489 Several NADs have been approved for ATTR treatment, including ASOs, such as inotersen 490,491 and eplontersen, 492 as well as siRNAs, such as patisiran 97 and vutrisiran
25.65
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2015;10: e0138340
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