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Key points: The wearing-off effect is normal during early treatment It seems follows a predictable pattern of lower hunger for the first 3-5 days, with hunger returning in the final few days before the next injection This pattern typically improves by weeks 4-8 of injections Why Mounjaro wears off between doses initially The wearing-off effect happens due to specific aspects of how Mounjaro works in your body: 1

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Skipping titration steps or increasing doses ahead of schedule amplifies the metabolic stress that triggers telogen effluvium

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