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& Colman, R

Lancet 2021;397:97184.ArticlePubMed 48

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GTP treatment decreased the mRNA levels of HDAC1, 2, and 3 in a gradual time course, whereas no such changes were observed with TSA

Intended strictly for research purposes

Notably, total IGF-I and IGFBPs were unchanged over this short-duration window, dissociating the observed bone-growth effect from sustained IGF-1 axis activation in this model