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Its worth noting that these gastrointestinal side effects are typically most pronounced when starting semaglutide or increasing the dose

doi:10.2174/138620706776055458

As of December 2025, a once-daily oral tablet formulation has also been approved

Diarrhea 29.7% of participants in research studying the gastrointestinal tolerability in patients taking semaglutide experienced diarrhea

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Further clinical evaluation (e.g., rheumatology referral) may be appropriate for patients who develop signs or symptoms of peripheral vasculopathy