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This differential efficiency of reprogramming was also reflected in the transcriptomes of these cells, as evaluated by the enrichment of a reprogramming score composed of genes previously reported in MEFs that are poised to reprogram at 72 h of OSKM expression 48 (Extended Data Fig

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Participants saw rapid initial loss through weeks 4 to 12, peak velocity between weeks 12 and 24 (roughly 1.8 pounds per week), gradual slowing between weeks 24 and 36, and a plateau or near-plateau by weeks 44 to 48

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