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In further research, it was found that the neuroprotection mediated by berberine after ischemia involves the AKT/glycogen synthase kinase-3 (GSK3)/extracellular signal-regulated kinase 1/2 (ERK 1/2) signal pathway, and inhibits Jun amino-terminal kinases (JNK) and caspase-3 activity (Simes Pires et al., 2014)

GIPR-Camper neurons of the AP were excited using a light-emitting diode (LED) light source (Dual Optoled, Cairn Research) at 435 nm for 50 ms every 3 s, and CFP and YFP emissions were simultaneously recorded after passing through an optosplit (Cairn Research

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Mattos Z, Debes JD, Vogel A et al (2022) Non-alcoholic fatty liver disease-related hepatocellular carcinoma: Is there a role for immunotherapy