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Cell Cycle 9 , 27192725 (2010)
Subcutaneous administration near the injury site provides both high local concentration and some systemic distribution as the peptide migrates to areas of damage throughout the body
MHRA-approved options include orlistat (prescription and over the counter), semaglutide (Wegovy, supported by NICE TA875), and liraglutide (Saxenda, supported by NICE TA664)
Some prefer abdominal subcutaneous injection for convenience, relying on systemic distribution
FDAs July 2026 briefing document states that the agency did not intend to issue a final determination until it considered committee input and completed its reviews
Continuing for 1-2 weeks after visible wound closure supports the ongoing remodeling phase where collagen continues maturing
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