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In both trials, participants were advised on lifestyle factors such as diet and exercise

Combination therapies for metabolic disease

The recommendation is not binding

In its off-label use for anti-aging or bodybuilding, it is used in doses of 200 to 300 g taken subcutaneously 2-3 times per day due to the short half-life

D-Allulose (also known as D-Psicose or, simply, allulose) is a low-calorie sweetener that occurs in small doses in wheat, fruits such as raisins, kiwis, and figs, and other sweet foods such as molasses, brown sugar, and maple syrup

Among the overlapped pathways (Supplementary Table 2), twenty-seven pathways, such as Hippo signaling pathway, TGF- signaling pathway, Wnt signaling pathway, tight and adherens junction, were up-regulated in APAP but down-regulated in CON and APAP_BSL