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This accumulative cycle results in the formation of atherosclerotic plaque deposits, which cause the arterial wall to protrude and disrupt blood flow, a process referred to as stenosis

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265,294,295 The proposed mechanisms involve the activation of the renin-angiotensin system, inflammatory responses, oxidative stress, vascular smooth muscle cell proliferation, and insulin resistance

10.1007/s12035-016-9839-9 3 AlamM.AhmedS.ElasbaliA

The same issue wouldn't be expected though when you take an injection

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