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As many treatments for neurological conditions have been hampered by limited permeability of the BBB, significant emphasis has been placed on research directed towards advanced drug delivery methods (Liu et al., 2025)

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For example, homocysteine (Hcy), an amino acid involved in DNA methylation, facilitates GPX4 methylation that leads to upregulation of oxidative stress and ferroptosis in nucleus pulposus (Zhang et al., 2020c)

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