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This observation suggests a possible dominant negative effect of the SIRT2 N168A mutant, as SIRT2 dimerization is crucial for SIRT2 deacetylase activity (Yang et al, 2023)

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The previously mentioned study on rats with open ischemic wounds also reported an apparent decrease in wound area of the GHK-Cu group that was greater compared to the control group on days 3 to 5, 6 to 9, and 11 to 13