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TRIUMPH-1 (NCT05929066), the Phase 3 registration trial for the obesity indication, reported topline results on May 21, 2026 : average weight loss of 28.3% at 80 weeks at the highest dose in 2,339 participants, versus 2.2% on placebo, and 30.3% at 104 weeks among participants with a BMI of 35 or above who continued in a pre-specified extension

While all GLP-1 medications effectively lower hemoglobin A1c and promote weight loss, they differ in dosing frequency, formulation, cardiovascular benefits, and side effect profiles

The combination outperformed both individual agents by a meaningful margin, and 60% of participants on the combination lost at least 20% of their body weight

Small, frequent meals of easily digestible foods (oatmeal, soup, boiled vegetables) taken every 34 hours help prevent hypoglycemia and nutrient gaps that can develop when appetite suppression is strongest