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Research Gaps: There are gaps in the research regarding the long-term use of L-Carnitine, especially in healthy individuals or at high doses

People with obesity or overweight (without T2DM) showed significant weight loss

Common side effects reported in trials include: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite Abdominal discomfort or bloating These effects are largely attributable to the drug's actions on gastric emptying and gut motility

Cardiovascular side effects, though generally mild, may include transient increases in heart rate of approximately two to four beats per minute on average

According to results from a multinational survey interviewing 3742 diabetic patients, an oral antidiabetic drug is preferable as the first choice of medication and medications for long-term use, especially for those with high HbA1c and comorbidities (obesity, hypertension, dyslipidaemia) [96]