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2.6 Other key regulatory pathways of ferroptosis 2.6.1 Nrf2 pathway-mediated antioxidant regulation of ferroptosis As the core transcription factor for cellular antioxidant stress, Nrf2 regulates ferroptosis via multiple pathways (125)
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Gao T, Wang X, Li Y, Ren F
When consumed as a standard powder or tablet, the fragile tripeptide structure is rapidly degraded by gastric enzymes (such as gamma-glutamyltransferase) and undergoes aggressive first-pass hepatic metabolism, reducing the amount of GSH in the blood [2]
Impairment of IGF-I gene splicing and MGF expression associated with muscle wasting [PMID: 16463438] Laboratory literature summary: Impairment of IGF-I gene splicing and MGF expression associated with muscle wasting
While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)
