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There is some evidence that the diabetes drug metformin (Glucophage) may reduce vitamin B12 absorption when used for several years

Previous study, suggests that DON oral dose induced anorexic POMC via NF-B activation by increasing the levels of proinflammatory cytokines in the hypothalamus and anorexic CCK production via increasing intestinal TRPA1 expression (84)

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[17] The importance of lysyl oxidase-derived cross-linking was established from animal studies in which lysyl oxidase was inhibited either by nutritional copper-deficiency or by supplementation of diets with -aminopropionitrile (BAPN), an inhibitor of lysyl oxidase

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Leptin is an effective treatment for hypothalamic amenorrhea