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[] Evolution of Anti-Obesity Medication: A Historical Perspective The development of anti-obesity medications has undergone a remarkable transformation over the past century, progressing from hazardous early attempts to increasingly sophisticated and safer treatments [Figure 2]

Analytical confirmation relies on HPLC at minimum, with mass spectrometry applied where peptide identity needs orthogonal confirmation

Both the nasal mucosa and lungs have large and highly vascularized surface areas for peptide absorption