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As there is no meaningful expression of GLP-1 receptors on hepatocytes, the major effect of GLP-1 agonists on MASH is likely to be indirect and may be related to a reduction in calorie intake, body weight and insulin resistance, all of which would lead to reduced liver lipid accumulation and hepatic inflammation 7,8

Long-Term Use of Certain Medications: Some common drugs interfere with B12 absorption: Metformin: A widely used diabetes drug

Beyond these clinically recognized effects, sustained caloric restriction during pharmacological weight reduction represents a chronic constraint on systemic energy flux

Segal, O

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