Additionally, semaglutide slows gastric emptying and improves insulin secretion, which improves glycemic control
Some of the commonly reported side effects include: Nausea Diarrhea Vomiting Constipation Abdominal pain Loss of appetite Headache Fatigue Dizziness These side effects are usually mild to moderate in intensity and tend to improve over time as the body adjusts to the medication
Overall mortality rates can range from 20 to 60%, especially in developing countries (Zhang et al
Together they increase GLP-1 receptor sites and reduce an enzyme that breaks down GLP-1 by 38 percent, which amplifies and prolongs GLP-1 action to reduce appetite and cravings
The majority of the emergencies involved gastrointestinal effects due to dosing errors, such as nausea/vomiting, abdominal pain and diarrhea, while 16% involved hypoglycemia, a known risk factor for semaglutides when they are combined with insulin, sulfonylureas or other drugs typically prescribed to diabetics and obese patients to reduce blood sugar
2022;54:e14602