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For PDE10A, Compound 86 , JY4 (co-crystallized ligand), and TAK-063 (standard), all occupied the P-clamp, interacting with I692, F696, and F729
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However, many want to avoid potential GLP-1 side effects
Retatrutide is still investigational and is not yet FDA-approved
Similarly, exendin-4 was demonstrated to inhibit inflammatory response in macrophages by Arakawa et al
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