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For the apoptosis test, the spheroids were treated with PBS, Ru(II)-OH, NP2, or NP4 for 24 h, respectively (Ru 10 M)

Caspase activation was also performed and the data totally confirmed these observations, with higher sensitivity for A549 shNRF2 and increased resistant for H23 NRF2 cell lines (Supplementary Fig

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Petersburg Institute of Bioregulation and Gerontology, it has been shown in research models to stimulate protein synthesis in testicular cells, modulate gene expression linked to steroidogenesis, influence stem cell differentiation into functional Leydig-lineage cells, and counteract age-related involution of reproductive tissues