Indeed, the introduction of a functional gut microbiome, which increases luminal SCFA availability, leads to reduced Insl5 expression, in a manner similar to refeeding calorie-restricted mice (169)
Significant amounts of detoxification also occur in the intestine, kidney, lungs, and brain, with phase I, II, and III reactions occurring throughout the rest of the body to a lesser degree [1]
Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronised progesterone versus placebo (KEEPS)
It enables the body to absorb adequate levels of calcium and phosphate, which keep bones healthy
Participants on the 5 mg dose lost an average of 16.0% of their body weight, roughly 35 pounds
So lets take a step back and look at what the actual research says