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Glutathione is exclusively made inside cells and is produced in two steps: The first makes gamma-glutamylcysteine (GGC) from the amino acids glutamate and cysteine, and the second adds a glycine to the gamma-glutamylcysteine (GGC) to make the GSH tripeptide

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IDO1 inhibitors have been tested in a variety of anti-cancer treatments, including epacadostat (Table 1), indoximod, and navoximod, but compared with the results of preclinical trials, the efficacy of IDO1 inhibitors alone have not been objectively reflected in the clinical trials (Soliman et al., 2016

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